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Early Clinical Development Initial clinical studies focused on evaluating safety, tolerability, pharmacokinetics, and biological activity

Table 2 summarized some of the clinical studies reported in the literature highlighting the clinical effectiveness of polyphenols in patients with CFS

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In healthy and insulin-resistant subjects, FCHO has been shown to improve insulin sensitivity [15, 16], but it is not clear whether a reduction in ectopic fat plays a role

Liraglutide attenuates nonalcoholic fatty liver disease through adjusting lipid metabolism via SHP1/AMPK signaling pathway